While the East may not have the vast areas of designated wilderness found in the West, there are still plenty of natural areas where you can have civilization far behind.
In Florida, you can look for alligators and waterfowl in the swamps of the Everglades.
Red wolves howl and black bears hunt for berries in Great Smoky Mountains National Park, a 780 square mile (2,000 km2) patch of wilderness that straddles the North Carolina-Tennessee border.
In the Appalachian Mountains, a contiguous stretch of back-country, large areas have changed little since the days of the Pilgrims.
In Canada, you can take a tour to see polar bears at Churchill, Manitoba, or to see seals at Magdalen Island in the Gulf of St. Laurence. Such tours are typical of the ways in which travelers can experience wildlife while supporting the economy, thus protecting the local ecosystem.